Is DMSO Cream Safe for Humans? Examining the Evidence
DMSO cream’s safety profile for human use is complex and nuanced. While potentially beneficial for certain conditions, it carries risks, and its safety hinges on concentration, application, and individual factors. Therefore, its use should be approached with caution and ideally under medical supervision.
Understanding DMSO: The Basics
Dimethyl sulfoxide (DMSO) is an organosulfur compound with a wide range of industrial and medicinal uses. As a solvent, it’s known for its ability to penetrate biological membranes, which is why it’s used to deliver other medications transdermally. The DMSO used in topical creams is typically derived from wood pulp as a byproduct of the paper-making process. While available in different formulations, creams and gels are generally favored for topical application because they offer more controlled delivery and reduce the risk of systemic absorption compared to liquid solutions.
Potential Benefits of DMSO Cream
DMSO cream has been explored for various potential therapeutic applications, primarily due to its claimed anti-inflammatory and analgesic properties. It is purported to help alleviate pain, reduce swelling, and accelerate healing. Some of the claimed benefits include:
- Pain Relief: May reduce pain associated with arthritis, nerve damage, and other conditions.
- Anti-inflammatory Effects: Can potentially decrease inflammation and swelling.
- Wound Healing: Possibly promotes faster healing of wounds and burns.
- Scleroderma Relief: Some studies suggest it might ease symptoms of scleroderma.
It’s crucial to note that while anecdotal evidence and some research suggest these benefits, more robust clinical trials are needed to definitively prove DMSO’s efficacy for these conditions. Many studies have yielded mixed results, and its effects can vary greatly from person to person.
Proper Application and Dosage
The safety of DMSO cream is heavily dependent on proper application and dosage. It’s essential to follow these guidelines:
- Concentration: Start with a low concentration (e.g., 15-25%) and gradually increase if tolerated. Higher concentrations increase the risk of side effects.
- Application Area: Apply to clean, dry skin. Avoid applying to broken skin, cuts, or irritated areas.
- Dosage: Apply a thin layer of cream and gently rub it in. Avoid overuse.
- Frequency: Use as directed by a healthcare professional or according to product instructions. Typically, applications are limited to a few times a day.
- Handwashing: Wash hands thoroughly after application to prevent accidental ingestion or contact with sensitive areas.
Potential Side Effects and Risks
DMSO is not without potential side effects. Understanding these risks is crucial before using DMSO cream.
- Skin Irritation: Redness, itching, burning, and dryness are common side effects, particularly at higher concentrations.
- Garlic-like Odor: DMSO can cause a distinctive garlic-like odor on the breath and skin. This is often a major deterrent for long-term use.
- Allergic Reactions: Some individuals may experience allergic reactions, ranging from mild rashes to severe anaphylaxis.
- Nausea and Vomiting: In rare cases, systemic absorption can lead to gastrointestinal upset.
- Drug Interactions: DMSO can enhance the absorption of other topical medications, potentially leading to increased side effects.
- Eye Irritation: Avoid contact with the eyes. DMSO can cause burning and irritation.
- Teratogenic Concerns: DMSO is not recommended for pregnant or breastfeeding women due to potential risks to the fetus or infant.
Factors Influencing Safety
Several factors can influence the safety of DMSO cream:
| Factor | Impact |
|---|---|
| Concentration | Higher concentrations increase the risk of skin irritation and systemic side effects. |
| Application Area | Broken or irritated skin increases absorption and the risk of adverse reactions. |
| Frequency of Use | Overuse can lead to cumulative exposure and increased risk of side effects. |
| Individual Sensitivity | Some individuals are more sensitive to DMSO than others. |
| Underlying Conditions | People with certain medical conditions (e.g., kidney or liver problems) may be at higher risk. |
Choosing a Reputable Product
Not all DMSO creams are created equal. It’s crucial to select a product from a reputable manufacturer that adheres to quality control standards. Look for products that are:
- USP Grade: Indicates that the DMSO meets standards for purity and quality.
- Third-Party Tested: Independent testing confirms the concentration and purity of the product.
- Clearly Labeled: Provides detailed information about ingredients, concentration, and usage instructions.
Avoid products from unknown or unreliable sources, as they may contain contaminants or be improperly formulated.
Frequently Asked Questions (FAQs) About DMSO Cream
1. Is DMSO cream FDA approved?
No, DMSO cream is not generally approved by the FDA for most uses. While it has been approved for treating interstitial cystitis, its use for other conditions is considered off-label and is not officially endorsed by the FDA. This means that the FDA has not evaluated its safety and efficacy for these other purposes.
2. Can DMSO cream interact with other medications?
Yes, DMSO can enhance the absorption of other topical medications, potentially increasing their effects and side effects. It’s crucial to inform your doctor about all medications you’re taking, including topical ones, before using DMSO cream.
3. What should I do if I experience side effects from DMSO cream?
If you experience any side effects, such as skin irritation, redness, or burning, discontinue use immediately and consult with a healthcare professional. For severe reactions, like difficulty breathing or swelling, seek immediate medical attention.
4. Is DMSO cream safe for long-term use?
The long-term safety of DMSO cream is not well-established. Prolonged use may increase the risk of side effects. It is best to use DMSO cream for short periods and under the guidance of a healthcare professional.
5. Can DMSO cream be used on pets?
DMSO is sometimes used in veterinary medicine, but the appropriate concentration and application methods differ significantly from human use. Consult with a veterinarian before using DMSO on your pet, as it can be dangerous if used improperly.
6. What is the difference between DMSO cream and DMSO gel?
The main difference is the consistency. Creams tend to be more moisturizing and spread easily, while gels are generally more concentrated and provide a cooling sensation. Both can be effective, but the choice depends on personal preference and the specific condition being treated.
7. How should DMSO cream be stored?
DMSO cream should be stored in a cool, dry place, away from direct sunlight and heat. Keep it out of reach of children and pets. It’s important to follow the storage instructions provided by the manufacturer.
8. Does DMSO cream have a shelf life?
Yes, DMSO cream does have a shelf life, typically indicated on the product packaging. Do not use the cream if it has expired, as its effectiveness and safety may be compromised.
9. Can I use DMSO cream if I have kidney or liver problems?
Individuals with kidney or liver problems should exercise caution when using DMSO cream, as these organs play a role in metabolizing and eliminating the substance. Consult with a doctor before using DMSO cream if you have any underlying medical conditions.
10. Can DMSO cream cure arthritis?
While DMSO cream may provide temporary pain relief for arthritis, it is not a cure for the condition. Arthritis is a chronic disease that requires ongoing management, which may include medication, physical therapy, and lifestyle modifications.
11. Is it safe to use DMSO cream during pregnancy or breastfeeding?
No, DMSO cream is generally not recommended during pregnancy or breastfeeding due to potential risks to the fetus or infant. There is limited research on its safety in these populations. It is best to avoid use entirely unless specifically advised by a doctor.
12. How quickly can I expect to see results from using DMSO cream?
The time it takes to see results from DMSO cream varies depending on the individual and the condition being treated. Some people may experience noticeable pain relief within a few days, while others may not see any improvement. If you don’t see any results after a few weeks, discontinue use and consult with a healthcare professional.